0 student filling test tubes in science lab

Alzheimer鈥檚 Disease Research Conducted By Houghton Students and Alumna

October 19, 2021

This summer, the Van Dyk Scholars of the Shannon Summer Research Institute, including current 黑料科 students, Isaiah Miller 鈥23, Blake Eby 鈥23, Evan Kasper 鈥23, Liam Fisher 鈥23, Skye Chaapel 鈥23, and recent graduate Bella Mancini 鈥21, conducted research on Alzheimer鈥檚 disease. This group of undergraduate researchers was overseen by 黑料科 professors Dr. Paul Martino, professor of Biochemistry, and Carmen McKell, associate professor of Data Science and director of Houghton鈥檚 Center for Data Science Analytics.

Data Science and Biochemistry Multidisciplinary Project

Using multiple sources including research papers and longitudinal patient databases (including drug history, medical diagnosis and lab results), the group utilized exploratory data analysis to screen and gather information about various chemicals and proteins that can cause the effects of Alzheimer鈥檚 disease and other forms of dementia. The exploratory data analysis provided a better understanding of the data set variables and the relationships between them and formed the foundation for more sophisticated data analysis and modeling in the future. This multidisciplinary experience allowed Data Science and Biochemistry student researchers to dive deeper into collaborative research and explore potential careers while contributing to a growing body of research.

Collaboration Leads to Better Research

鈥淲atching this group of students use their data science skills to solve a complex problem like the treatment of Alzheimer鈥檚 disease was one of the most rewarding aspects of this research project,鈥 shares Professor Carmen McKell. 鈥淒ata science is best learned by doing, and these students were deeply engaged and self-directed, using critical thinking skills to decide what to do next to draw insights from a vast amount the data. Through collaboration, the data science students were able to enhance their domain knowledge by learning as much as possible from the biochemistry students. This gave them the context needed to interpret and validate their results. Hands-on collaborative opportunities like this give Houghton students the ability to positively impact people鈥檚 lives thereby fulfilling our mission to equip students to lead and labor as scholar-servants in a changing world.鈥

Real-World Impact

With Alzheimer鈥檚 disease and other forms of dementia currently impacting over , research into causes and treatments is vital. Alzheimer鈥檚 research has been a specialty of Dr. Martino since 1991, when he began exploring the topic as a graduate student. His expertise in the field made him the ideal candidate to recruit Houghton students to partner with him in this opportunity to have a real-world impact on the scientific body of research and the very real lives that research benefits. Thanks to the generous investment that led to the creation of the Van Dyk Scholars and the Shannon Summer Research Institute, Houghton students gained valuable experience that will benefit them in their future careers while exploring ways to help prevent the devastation diseases like Alzheimer鈥檚 can have on families and communities.

Hands-On Preparation for Graduate Studies and Careers

As a part of the Shannon Summer Research Institute and the Van Dyk Scholars program, Houghton students spent the summer on graduate-level research and were able to identify promising drug candidates that may help early treatment of Alzheimer鈥檚 disease. Each student now has the experience of soon-to-be-published graduate-level research that will greatly impact this vital area of study. This experience also provides student researchers with a deeper understanding of what they may want to study in graduate school and prepares them to work in a professional collaborative setting.

鈥淢y favorite aspect of this summer was the dynamic that the group shared and the spontaneous conversation that developed from that,鈥 shares Dr. Paul Martino. 鈥淗ands-on experience such as this helps Houghton students to accelerate their learning through a Christ-centered education. It promotes career-readiness and allows them to hit the ground running after graduation with a straight trajectory towards their professional and academic goals.鈥

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